|
KMID : 0381920110410020129
|
|
Korean Journal of Microscopy
2011 Volume.41 No. 2 p.129 ~ p.137
|
|
|
Inhibitory Effects of Nude Pack Containing Black Tea Water Extract on Skin Wrinkle Formation in Hairless Mice
|
|
Kim Young-Chul
Park Eun-Ye
Kim Sang-Nam
Yoo Ying-Gi
Park Mi-Soon
Lee Gui-Young
Lee Suk-Jun
Chang Byung-Soo
|
|
|
Abstract
|
|
|
|
The aim of this study was to evaluate the inhibitory effect of nude pack containing black tea water extract (NPBT) on skin wrinkle formation in hairless mice. Skin wrinkles were induced by UVB irradiation to the backs of hairless mice for 5 weeks. And at the same time, NPBT was applied topically. Wrinkle formation, histological changes, expression of matrix metalloproteinase-3 (MMP-3) and protein activities of MMP-2 and MMP-9 were observed or analyzed. Wrinkles for the control group were formed as a pattern of deep furrows and thick crests. Whereas wrinkles for the NPBT treated group were formed as a pattern of shallow furrows and thin crests, and their wrinkle areas were significantly (p?0.001) lower than the control group. Collagen fibers were arranged irregularly and sparse in density and some elastic fibers were degenerated in the control group, while they were almost intact in the NPBT treated group. MMP-3 mRNA expression in the control group was significantly (p?0.001) higher than the normal group, and that of NPBT treated group was significantly (p?0.001) lower than the control group. The NPBT treated group showed remarkably lower protein activities of MMP-2 and MMP-9 than the control group. NPBT could have a considerable inhibitory effect on skin wrinkle formation in hairless mice.
|
|
|
KEYWORD
|
|
|
Black tea extract, Collagen fiber, Hairless mice, MMP, Wrinkles
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|